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MB-07729

Names

[ CAS No. ]:
882755-95-5

[ Name ]:
MB-07729

[Synonym ]:
{5-[2-amino-5-(2,2-dimethylpropionyl)thiazol-4-yl]furan-2-yl}phosphonic acid
{5-[2-amino-5-(2,2-dimethylpropionyl)thiazol-4-yl]-furan-2-yl}phosphonic acid

Biological Activity

[Description]:

MB-07729 is a potent fructose 1,6-bisphosphatase (FBPase) noncompetitive inhibitor with IC50 values of 31, 121, and 189 nM for human, monkey, and rat, respectively.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

31, 121, and 189 nM for human, monkey, and rat, respectively [1] .


[References]

[1]. PAUL D. VAN POELJE，et al. MB07803, a Prodrug of a Second Generation Fructose-1,6-Bisphosphatase Inhibitor, Lowers Blood Glucose in Diabetic Rodents and in Cynomolgus Monkeys.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Molecular Formula ]:
C12H15N2O5PS

[ Molecular Weight ]:
330.29700

[ Exact Mass ]:
330.04400

[ PSA ]:
164.70000

[ LogP ]:
2.59830

Related Compounds