Fmoc-amino-PEG5-acid

Names

[ Name ]:
Fmoc-amino-PEG5-acid

[Synonym ]:
fmoc-18-amino-4,7,10,13,16-pentaoxaoctadecanoic acid
5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid 1-(9H-fluoren-9-ylmethyl) ester

Biological Activity

[Description]:

Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.210±0.06 g/cm3 (20ºC 760 Torr)

[ Boiling Point ]:
711.4±60.0°C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₇NO₉

[ Molecular Weight ]:
531.59500

[ Exact Mass ]:
531.24700

[ PSA ]:
121.78000

[ LogP ]:
3.47370

Safety Information

[ HS Code ]:
29225090

Fmoc-amino-PEG5-acid

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds