4-Deoxypyridoxine 5'-phosphate

Names

[ CAS No. ]:
883-84-1

[ Name ]:
4-Deoxypyridoxine 5'-phosphate

[Synonym ]:
1ggn
vitamin B-6
PLR
Deoxypyridoxine-P
4-Deoxypyridoxine 5'-phosphate
4-Desoxy-pyridoxol-phosphat
4-Deoxypyridoxin-5'-phosphat

Biological Activity

[Description]:

4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Metabolic Disease

[Target]

Sphingosine 1-phosphate (S1P)[1] Ornithine decarboxylase[2] Glutamate apodecarboxylase[3]

[References]

[1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216.

[2]. M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9.

[3]. D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32.

Chemical & Physical Properties

[ Density]:
1.499g/cm3

[ Boiling Point ]:
567.6ºC at 760 mmHg

[ Molecular Formula ]:
C₈H₁₂NO₅P

[ Molecular Weight ]:
233.15800

[ Flash Point ]:
297.1ºC

[ Exact Mass ]:
233.04500

[ PSA ]:
109.69000

[ LogP ]:
1.01330

[ Index of Refraction ]:
1.59

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%