2-Benzylsuccinic acid

Names

[ CAS No. ]:
884-33-3

[ Name ]:
2-Benzylsuccinic acid

[Synonym ]:
Butanedioic acid, 2-(phenylmethyl)-
2-Benzylsuccinic acid
Benzyl butanedioic acid
DL-BENZYLSUCCINIC ACID
alpha-Benzylsuccinic acid
2-benzylbutanedioic acid
MFCD00055798

Biological Activity

[Description]:

2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an potent inhibitor of carboxypeptidase A (CPA)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carboxypeptidase

[References]

[1]. Mark P. Wentland, et al. 96-Well Plate Colorimetric Assay for Ki Determination of (+/-)-2-Benzylsuccinic Acid, an Inhibitor of Carboxypeptidase A: A Laboratory Experiment in Drug Discovery. J Chem Educ. 2004 Mar 1, 81 (3):398.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
331.4±22.0 °C at 760 mmHg

[ Melting Point ]:
161-163°C

[ Molecular Formula ]:
C₁₁H₁₂O₄

[ Molecular Weight ]:
208.211

[ Flash Point ]:
168.4±18.8 °C

[ Exact Mass ]:
208.073563

[ PSA ]:
74.60000

[ LogP ]:
1.60

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.568

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2917399090

Customs

[ HS Code ]: 2917399090

[ Summary ]:
2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Regulation of cytoplasmic tubulin carboxypeptidase activity in vitro by cations and sulfhydryl-modifying compounds.

J. Cell. Biochem. 60(3) , 424-36, (1996)

alpha-tubulin subunits within microtubules (MTs) can be post-translationally detyrosinated by a tubulin-specific carboxypeptidase (TCP) activity to form biochemically distinct MTs. Attempts to charact...

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

PLoS ONE 6(4) , e19270, (2011)

Nerve injury leads to sensitization mechanisms in the peripheral and central nervous system which involve transcriptional and post-transcriptional modifications in sensory nerves. To assess protein re...

The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen.

EMBO J. 16(23) , 6906-13, (1997)

The three-dimensional structure of human procarboxypeptidase A2 has been determined using X-ray crystallography at 1.8 A resolution. This is the first detailed structural report of a human pancreatic ...