R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE

Names

[ Name ]:
R(+)-3-(3-HYDROXYPHENYL)-N-PROPYLPIPERIDINE HYDROCHLORIDE

[Synonym ]:
(+)-3-PPP hydrochloride
(+)-PPP hydrochloride
N-Benzyl-4-(p-tolylamino)piperidine-4-carboxamide
(+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine hydrochloride
R(+)-3-(3-hydroxyphenyl)-N-n-propylpiperidine hydrochloride
(-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine hydrochloride

Biological Activity

[Description]:

(R)-Preclamol hydrochloride ((+)-3-PPP hydrochloride) is the R-enantiomer of Preclamol hydrochloride. (R)-Preclamol hydrochloride is a DA agonist with autoreceptor as well as postsynaptic receptor stimulatory properties[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Hjorth S, et al. Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP. Psychopharmacology (Berl). 1983;81(2):89-99.

[2]. Arnt J, et al. Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers. Psychopharmacology (Berl). 1983;81(3):199-207.

Chemical & Physical Properties

[ Boiling Point ]:
342.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₂ClNO

[ Molecular Weight ]:
255.78

[ Flash Point ]:
158ºC

[ Exact Mass ]:
255.13900

[ PSA ]:
23.47000

[ LogP ]:
3.72150

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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