Biotin-C5-amino-C5-amino

Names

[ CAS No. ]:
89889-51-0

[ Name ]:
Biotin-C5-amino-C5-amino

[Synonym ]:
D-biotinylaminohexanoylaminohexanoic acid
D-biotin-Acp-Acp-OH
N-Biotinylcaproylaminocaproic Acid

Biological Activity

[Description]:

Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₃₈N₄O₅S

[ Molecular Weight ]:
470.62600

[ Exact Mass ]:
470.25600

[ PSA ]:
172.40000

[ LogP ]:
3.79940

[ Storage condition ]:
2-8°C

Biotin-C5-amino-C5-amino

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds