beta-Rhamnocitrin

Names

[ CAS No. ]:
90-19-7

[ Name ]:
beta-Rhamnocitrin

[Synonym ]:
2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxychromen-4-one
MFCD00016931
7-O-Methyl Quercetin
EINECS 201-974-1

Biological Activity

[Description]:

Rhamnetin is a quercetin derivative found in Coriandrum sativum, inhibits secretory phospholipase A2, with antioxidant and anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Inflammation/Immunology

[References]

[1]. Novo Belchor M, et al. Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2. Molecules. 2017 Aug 31;22(9).

Chemical & Physical Properties

[ Density]:
1.634g/cm3

[ Boiling Point ]:
627.9ºC at 760 mmHg

[ Melting Point ]:
293-296°C (dec.)

[ Molecular Formula ]:
C₁₆H₁₂O₇

[ Molecular Weight ]:
316.26200

[ Flash Point ]:
238.9ºC

[ Exact Mass ]:
316.05800

[ PSA ]:
120.36000

[ LogP ]:
2.29100

[ Index of Refraction ]:
1.74

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8748000

CHEMICAL NAME :: Flavone, 7-methoxy-3,3',4',5-tetrahydroxy-

CAS REGISTRY NUMBER :: 90-19-7

BEILSTEIN REFERENCE NO. :: 0047741

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H12-O7

MOLECULAR WEIGHT :: 316.28

WISWESSER LINE NOTATION :: T66 BO EVJ CR CQ DQ& DQ GQ IO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 166 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 54,297,1978

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LK8748000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.

Fitoterapia 98 , 11-21, (2014)

The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivativ...

[Non-alkaloid chemical constituents from Coptis chinensis].

Zhongguo Zhong Yao Za Zhi 37(9) , 1241-4, (2012)

To separate and identify chemical constituents from Coptis chinensis.The compounds were separated and purified by various chromatographic techniques. Their structures were identified on the basis of t...

Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H₂O₂-induced apoptosis.

J. Ethnopharmacol. 153(3) , 552-60, (2014)

Many studies have emphasized that flavonoids, found in various fruits, vegetables, and seeds, as well as tea and red wine, have potential health-promoting and disease-preventing effects. Rhamnetin is ...