Thrombin

[Description]:

Thrombin is a trypsin-like allosteric serine protease that has a fundamental role in the clotting cascade.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Thrombin

Research Areas >> Neurological Disease

[In Vitro]

Thrombin is a serine protease known to have a fundamental role in the clotting cascade. In addition, Thrombin also mediates several cellular processes through a unique family of protease-activated receptors (PARS), where PAR-1 is the prototype. Thrombin and PAR-1 are highly expressed in the brain and regulate synaptic transmission and plasticity[1]. Thrombin belongs to the chymotrypsin family and is generated by proteolytic cleavage of its inactive precursor prothrombin by the proThrombinase complex. Thrombin mediates the conversion of fibrinogen to fibrin, the main constituent of a blood clot. Furthermore, Thrombin activates the blood coagulation factors V, VIII, XI, XIII and the anticoagulant protein C[2].

[References]

[1]. Golderman V, et al. Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus. J Mol Neurosci. 2018 Dec 4.

[2]. Krenzlin H, et al. The Importance of Thrombin in Cerebral Injury and Disease. Int J Mol Sci. 2016 Jan 11;17(1).

[Related Small Molecules]

[ Appearance of Characters ]:
powder | white

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: 1 mL/vial clear to slightly hazy, colorless solution

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn,B,Xi

[ Risk Phrases ]:
36/37/38-42

[ Safety Phrases ]:
22-24/25-36/37-26-24

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
XO8950000

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