Polyacrylic acid
Names
[ CAS No. ]:
9003-01-4
[ Name ]:
Polyacrylic acid
[Synonym ]:
PAA
Poly(acrylic acid)
Propenoic acid polymer
EINECS 618-347-7
Acrylic acid polymer
MFCD00084394
2-Propenoic acid homopolymer
Carbomer 940
Polyacrylic acid
Carbomer 934
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.09 (30% aq.)
[ Boiling Point ]:
116ºC
[ Melting Point ]:
106ºC
[ Molecular Formula ]:
(C3H4O2)x
[ Molecular Weight ]:
2000(Average)
[ Flash Point ]:
61.6ºC
[ Exact Mass ]:
72.02110
[ PSA ]:
37.30000
[ LogP ]:
0.25700
[ Index of Refraction ]:
n20/D 1.442
[ Water Solubility ]:
Soluble in water.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AT4680000
- CHEMICAL NAME :
- Acrylic acid, polymers
- CAS REGISTRY NUMBER :
- 9003-01-4
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- (C3-H4-O2)x
- MOLECULAR WEIGHT :
- 168.06
- WISWESSER LINE NOTATION :
- /*1Y*VQ/
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,721,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,652,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ZMEIAV Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii. Journal of Microbiology, Epidemiology, and Immunology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.14- 1935- Volume(issue)/page/year: (9),14,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 114,258,1958 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,47,1979 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,47,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82129 No. of Facilities: 2084 (estimated) No. of Industries: 44 No. of Occupations: 55 No. of Employees: 34007 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7610 No. of Facilities: 31268 (estimated) No. of Industries: 198 No. of Occupations: 162 No. of Employees: 571954 (estimated) No. of Female Employees: 232712 (estimated)
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H340-H350
[ Precautionary Statements ]:
P201-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
[ Hazard Codes ]:
C: Corrosive;T: Toxic;Xi: Irritant;
[ Risk Phrases ]:
45-46-34-36/37/38
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
UN 3265 8/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
AT4680000
[ HS Code ]:
3906909090
Customs
[ HS Code ]: 3906909090
Articles
AAPS PharmSciTech 14(1) , 301-11, (2013)
The controlled release of diflunisal and fluconazole from tablets made of novel polymers, poly(acrylic acid) (PAA) crosslinked with either β-cyclodextrin (βCD) or hydroxypropyl-βCD (HPβCD), was invest...
Cyclodextrin-crosslinked poly(acrylic acid): Synthesis, physicochemical characterization and controlled release of diflunisal and fluconazole from hydrogels.Int. J. Pharm. 444(1-2) , 175-84, (2013)
The aim of this work was to develop mucoadhesive hydrogels with variable drug delivery properties by crosslinking poly(acrylic acid) (PAA) with cyclodextrins (CDs). CD-PAA polymers with high CD conten...
Chest wall reconstruction using biomaterials.Ann. Thorac. Surg. 95(3) , 1050-6, (2013)
Skeletal chest wall reconstruction can be a challenge, depending on the indication, location, and health of the patient; various materials are available. Recently, biomaterials that are remodelable (b...