Chymotrypsin

Names

[ Name ]:
Chymotrypsin

[Synonym ]:
alpha-chymarophth
alfapsin
catarase
alphachymar
alpha-chymotrypsinfrombovinepancreas
MFCD00130481
avazyme
chymar
chymolase

Biological Activity

[Description]:

Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease

Research Areas >> Others

[References]

[1]. W.R. Terra, et al. 4.5 - Biochemistry of Digestion, Editor(s): Lawrence I. Gilbert, Comprehensive Molecular Insect Science, Elsevier, 2005, Pages 171-224.

[2]. Steven W. Cotton. Chapter 33 - Evaluation of exocrine pancreatic function, Editor(s): William Clarke, Mark A. Marzinke, Contemporary Practice in Clinical Chemistry (Fourth Edition), Academic Press, 2020, Pages 573-585.

Chemical & Physical Properties

[ Melting Point ]:
127°C

[ Appearance of Characters ]:
salt-free, lyophilized powder | white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
Reconstitute in 1mM HCl. Soluble at 10mg/ml in 1mM HCl. 2mM calcium chloride serves as a stabilizer. Store aliquoted solutions at -20°C for up to a week.

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn,B

[ Risk Phrases ]:
36/37/38-42/43-42

[ Safety Phrases ]:
26-36-36/37-24-22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GC3050000

Articles

Lung injury-dependent oxidative status and chymotrypsin-like activity of skeletal muscles in hamsters with experimental emphysema.

BMC Musculoskelet. Disord. 14 , 39, (2013)

Peripheral skeletal muscle is altered in patients suffering from emphysema and chronic obstructive pulmonary disease (COPD). Oxidative stress have been demonstrated to participate on skeletal muscle l...

Purification, crystallization and preliminary X-ray analysis of the membrane-bound [NiFe] hydrogenase from Allochromatium vinosum.

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64(Pt 8) , 719-22, (2008)

The membrane-bound [NiFe] hydrogenase is a unique metalloprotein that is able to catalyze the reversible oxidation of hydrogen to protons and electrons during a complex reaction cycle. The [NiFe] hydr...

Preparation and thermo-reversible gelling properties of protein isolate from defatted Antarctic krill (Euphausia superba) byproducts.

Food Chem. 188 , 170-6, (2015)

Protein isolate was prepared from defatted Antarctic krill (Euphausia superba) byproducts by 0.1 M NaOH extraction. Maximum yield of krill protein isolate reached 28.66% by precipitation at pH 4.6. Kr...