1-(2-Chlorobenzyl)-3-(4-nitrophenyl)thiourea

Names

[ CAS No. ]:
900701-83-9

[ Name ]:
1-(2-Chlorobenzyl)-3-(4-nitrophenyl)thiourea

[Synonym ]:
1-(2-Chlorobenzyl)-3-(4-nitrophenyl)thiourea
Thiourea, N-[(2-chlorophenyl)methyl]-N'-(4-nitrophenyl)-
MFCD04154139

Biological Activity

[Description]:

InhA-IN-3 (Compound TU12) is a Mycobacterium tuberculosis InhA (an enoyl ACP-reductase) inhibitor with an IC50 of 17.7 μM[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 17.7 μM (InhA)[1]


[In Vitro]

InhA-IN-3 (Compound TU12) shows antitubercular activity with a MIC of 0.78±0.59 µg/mL against Mycobacterium tuberculosis[1].

[References]

[1]. Doğan ŞD, et al. Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors. Eur J Med Chem. 2020 Aug 1;199:112402.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
478.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H12ClN3O2S

[ Molecular Weight ]:
321.782

[ Flash Point ]:
243.1±31.5 °C

[ Exact Mass ]:
321.033875

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.709

Related Compounds