Lysostaphin

Names

[ Name ]:
Lysostaphin

[Synonym ]:
2-(3,5-Dimethoxyphenyl)-4(1H)-quinazolinone
2-(3,5-dimethoxyphenyl)quinazolin-4-ol
4(1H)-Quinazolinone, 2-(3,5-dimethoxyphenyl)-

Biological Activity

[Description]:

Lysostaphin is an antistaphylococcal agent. Lysostaphin has activities of three enzymes namely, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase[1].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Jaspal K Kumar, et al. Lysostaphin: An Antistaphylococcal Agent. Appl Microbiol Biotechnol. 2008 Sep;80(4):555-61.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
483.6±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₄N₂O₃

[ Molecular Weight ]:
282.294

[ Flash Point ]:
246.3±31.5 °C

[ Exact Mass ]:
282.100433

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22;S24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
OL5985000

Articles

Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureus.

Infect. Immun. 76(4) , 1333-9, (2008)

Thymidine-dependent small-colony variants (SCVs) of Staphylococcus aureus are frequently associated with persistent and recurrent infections in cystic fibrosis patients. The phenotypic appearance of S...

Targeting methicillin-resistant Staphylococcus aureus with short salt-resistant synthetic peptides.

Antimicrob. Agents Chemother. 58(7) , 4113-22, (2014)

The seriousness of microbial resistance combined with the lack of new antimicrobials has increased interest in the development of antimicrobial peptides (AMPs) as novel therapeutics. In this study, we...

Leukocyte cell-derived chemotaxin 2 is a zinc-binding protein.

FEBS Lett. 587(5) , 404-9, (2013)

Leukocyte cell-derived chemotaxin 2 (LECT2) is a secreted hepatic protein that has been associated with several physiological activities. LECT2 belongs to the peptidase M23 family, suggesting that it ...