Di-4-ANEPPS

Names

[ Name ]:
Di-4-ANEPPS

[Synonym ]:
4-(2-(6-(DIBUTYLAMINO)-2-NAPHTHALENYL)ETHENYL)-1-(3-SULFOPROPYL)PYRIDINIUM HYDROXIDE INNER SALT
MFCD03453609
di-N-butylaminonaphthylethenylpyridiniumpropylsulfonate

Biological Activity

[Description]:

Di-4-ANEPPS is a voltage-sensitive dye in membrane potential. Di-4-ANEPPS allows reaching a time resolution better than 1 ms and exhibits changes in fluorescence of up to 10% per 100 mV. Di-4-ANEPPS is a common tool for mapping cardiac electrical activity. Di-4-ANEPPS demonstrate significant direct irreversible effect on spontaneous heart rate and ventricular impulse conduction in rabbit isolated heart model[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Marina Ronzhina, et al. Di-4-ANEPPS Modulates Electrical Activity and Progress of Myocardial Ischemia in Rabbit Isolated Heart. Front Physiol. 2021 Jun 10;12:667065.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₆N₂O₃S

[ Molecular Weight ]:
480.66

[ Exact Mass ]:
480.24500

[ PSA ]:
72.70000

[ LogP ]:
6.72040

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice.

PLoS ONE 9(7) , e101838, (2014)

Inherited dilated cardiomyopathy (DCM) is characterized by dilatation and dysfunction of the ventricles, and often results in sudden death or heart failure (HF). Although angiotensin receptor blockers...

MeCP2 regulates the timing of critical period plasticity that shapes functional connectivity in primary visual cortex.

Proc. Natl. Acad. Sci. U. S. A. 112 , E4782-91, (2015)

Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome, an autism spectrum-associated disorder with a host of neurological and sensory symptoms, but the pathogenic mechanisms remain elu...

Long-Term Spatiotemporal Reconfiguration of Neuronal Activity Revealed by Voltage-Sensitive Dye Imaging in the Cerebellar Granular Layer.

Neural Plast. 2015 , 284986, (2015)

Understanding the spatiotemporal organization of long-term synaptic plasticity in neuronal networks demands techniques capable of monitoring changes in synaptic responsiveness over extended multineuro...