TC-FPR 43
Names
[ CAS No. ]:
903895-98-7
[ Name ]:
TC-FPR 43
Biological Activity
[Description]:
FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist[1][2].
[Related Catalog]:
[Target]
FPR1, FPR2/ALX[1]
[In Vitro]
FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells[1]. FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM)[1]. FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells[2]. Cell Viability Assay[1] Cell Line: Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors Concentration: 10-5, 10-3, 0.1, 10, 1000, 105, 107 nM Incubation Time: Result: Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC50 =11.6±1.9 nM).
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H21ClN4O2
[ Molecular Weight ]:
384.86
[ Storage condition ]:
2-8℃