beta-D-Glucan

Names

[ Name ]:
beta-D-Glucan

[Synonym ]:
β-D-Glucopyranosyl-(1->4)-(4ξ)-β-D-xylo-hexopyranosyl-(1->4)-(4ξ)-α-D-xylo-hexopyranose
Carbamic acid,(1,1-dimethyl-2-propynyl)-,2-fluoroethyl ester
α-D-xylo-Hexopyranose, O-β-D-glucopyranosyl-(1->4)-O(4ξ)-β-D-xylo-hexopyranosyl-(1->4)-, (4ξ)-
beta-D-Glucan

Biological Activity

[Description]:

β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery[1]. β-d-glucan is an enteric delivery vehicle for probiotics[2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Cancer

[In Vitro]

β-D-glucan dissolved in DMSO but not water inhibits MCF-7 cell proliferation in a concentration-dependent manner as measured by BrdU incorporation with an IC50 of ∼164 μg/mL. β-D-glucan dissolved in DMSO inhibits tamoxifen/endocrine-resistant LCC9 and LY2 cell proliferation with IC50 values of 4.6 and 24.2 μg/mL, respectively[3].

[References]

[1]. Su Y, et al. pH-sensitive PEG-coated hyper-branched β-d-glucan derivative as carrier for CpG oligodeoxynucleotide delivery. Carbohydr Polym. 2020;246:116621.

[2]. Gani A, et al. β-d-glucan as an enteric delivery vehicle for probiotics. Int J Biol Macromol. 2018;106:864-869.

[3]. Jafaar ZM, et al. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression. Int J Oncol. 2014;44(4):1365-1375.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
865.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₃₂O₁₆

[ Molecular Weight ]:
504.437

[ Flash Point ]:
477.0±34.3 °C

[ Exact Mass ]:
504.169037

[ PSA ]:
268.68000

[ LogP ]:
-3.25

[ Appearance of Characters ]:
powder

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.673

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 20 mg/mL, clear, faintly yellow

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LZ3985000

Articles

(1,3)-β-D-glucan as a prognostic marker of treatment response in invasive candidiasis.

Clin. Infect. Dis. 55(4) , 521-6, (2012)

(1,3)-β-D-glucan (BG) is a biomarker for invasive candidiasis (IC). The usefulness of BG level as a prognostic marker of treatment outcome is not well characterized.Two hundred fifty-seven patients wi...