Inotilone

Names

[ Name ]:
Inotilone

[Synonym ]:
2-[[3,4-bis(oxidanyl)phenyl]methylidene]-5-methyl-furan-3-one
2-[(3,4-dihydroxyphenyl)methylidene]-5-methyl-3-furanone
inotilone

Biological Activity

[Description]:

Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

[Target]

MMP-2, MMP-9, NFκB p65, IκBα[1]

[References]

[1]. Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. Sci Rep. 2019 Feb 20;9(1):2344.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₁₀O₄

[ Molecular Weight ]:
218.21

[ Exact Mass ]:
218.05800

[ PSA ]:
66.76000

[ LogP ]:
1.94180