chymostatin

Names

[ Name ]:
chymostatin

[Synonym ]:
N-{[(1S)-1-[(4S)-2-Amino-1,4,5,6-tetrahydro-4-pyrimidinyl]-2-{[(2S)-4-methyl-1-oxo-1-{[(2S)-1-oxo-3-phenyl-2-propanyl]amino}-2-pentanyl]amino}-2-oxoethyl]carbamoyl}-L-phenylalanine
MFCD00071059
CHYMOSTATIN (MICROBIAL PRODUCT)
Chymostatin
CHYMOSTATIN, 5 MG
L-Phenylalanine, N-[[[(1S)-2-[[(1S)-1-[[[(1S)-1-formyl-2-phenylethyl]amino]carbonyl]-3-methylbutyl]amino]-1-[(4S)-hexahydro-2-imino-4-pyrimidinyl]-2-oxoethyl]amino]carbonyl]-
CHYMOSTATIN (25 MG )
CHYMOSTATIN (ACTINOMYCETES)

Biological Activity

[Description]:

Chymostatin is a potent cathepsin G inhibitor. Chymostatin inhibits fungal growth when combined with other pepsin inhibitors. Chymostatin can be used for acute lung injury and pancreatitis research[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

[References]

[1]. Chen Yang, et al. Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
276-278℃

[ Molecular Formula ]:
C₃₁H₄₁N₇O₆

[ Molecular Weight ]:
607.701

[ Exact Mass ]:
607.311829

[ PSA ]:
201.61000

[ LogP ]:
4.00

[ Index of Refraction ]:
1.640

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: 10 mM Stock solutions stable for months at −20 °C.

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-24/25-36-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
GC3047700

Articles

Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei.

PLoS ONE 10 , e0134723, (2015)

The filamentous fungus Trichoderma reesei has tremendous capability to secrete proteins. Therefore, it would be an excellent host for producing high levels of therapeutic proteins at low cost. Develop...

Estrogen inhibits mast cell chymase release to prevent pressure overload-induced adverse cardiac remodeling.

Hypertension 65(2) , 328-34, (2015)

Estrogen regulation of myocardial chymase and chymase effects on cardiac remodeling are unknown. To test the hypothesis that estrogen prevents pressure overload-induced adverse cardiac remodeling by i...

Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism.

Am. J. Physiol. Heart Circ. Physiol. 305(5) , H644-50, (2013)

Angiotensin-(1-12) [ANG-(1-12)], a new member of the renin-angiotensin system, is recognized as a renin independent precursor for ANG II. However, the processing of ANG-(1-12) in the circulation in vi...