Benzyl-PEG10-alcohol

Names

[ CAS No. ]:
908258-44-6

[ Name ]:
Benzyl-PEG10-alcohol

[Synonym ]:
decaethylene glycol monobenzyl ether
1-Phenyl-2,5,8,11,14,17,20,23,26,29-decaoxahentriacontan-31-ol

Biological Activity

[Description]:

Benzyl-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₄₈O₁₁

[ Molecular Weight ]:
548.66300

[ Exact Mass ]:
548.32000

[ PSA ]:
112.53000

[ LogP ]:
1.34490

Benzyl-PEG10-alcohol

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds