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α-Helical CRF(9-41)

Names

[ CAS No. ]:
90880-23-2

[ Name ]:
α-Helical CRF(9-41)

Biological Activity

[Description]:

α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CRFR
Research Areas >> Neurological Disease

[Target]

KB: ~100 nM (CRF2 receptor)[2] EC50: 140 nM (CRF1 receptor)[2]


[References]

[1]. Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6.

[2]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35.

Chemical & Physical Properties

[ Molecular Formula ]:
C166H274N46O53S2

[ Molecular Weight ]:
3826.40

Related Compounds