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Cl-HIBO

Names

[ CAS No. ]:
909400-43-7

[ Name ]:
Cl-HIBO

[Synonym ]:
Cl-HIBO
4-CHLOROHOMOIBOTENIC ACID

Biological Activity

[Description]:

Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively). Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM). Cl-HIBO has desensitizing properties[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

EC50: 4.7, 1.7, 2700 and 1300 μM=GluR1/2/3/4[1]


[In Vitro]

Cl-HIBO is a strongly desensitizing full agonist at GluR1[1].

[References]

[1]. Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). J Med Chem. 2003;46(11):2246-2249.

Chemical & Physical Properties

[ Molecular Formula ]:
C6H7ClN2O4

[ Molecular Weight ]:
206.58400

[ Exact Mass ]:
206.00900

[ PSA ]:
109.58000

[ LogP ]:
0.68830

Related Compounds