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7-Keto-3α,12-α-dihydroxycholanic Acid

Names

[ CAS No. ]:
911-40-0

[ Name ]:
7-Keto-3α,12-α-dihydroxycholanic Acid

[Synonym ]:
(3alpha,5beta,12alpha)-3,12-Dihydroxy-7-oxocholan-24-oic acid
7-Ketodeoxycholic acid
7-ketodeoxycholate
(4R)-4-[(3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
7-oxodeoxycholate
3alpha,12alpha-Diol-7-one-5beta-cholanoic acid
3alpha,12alpha-Dihydroxy-7-oxo-5beta-cholan-24-oic Acid
7-Oxodeoxycholic acid
3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanic acid
3a,12a-dihydroxy-7-oxo-5b-cholan-24-oic acid
7-Keto-3α,12-α-dihydroxycholanic Acid

Biological Activity

[Description]:

7-keto-lithocholic acid is a metabolite of bile acids in Clostridium absonum. 7-keto-lithocholic acid is also converted from Lactobacillus and Bifidobacterium with specific condition[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

7-keto-lithocholic acid shows an increasing bioconversion rate with addition of an equimolar concentration of deoxycholic acid (which itself is not metabolized)[1]. 7-keto-lithocholic acid is induced by deoxycholic acid and then it's metabolized[1]. E. lentum-like c-25 converts 81.7% of 2 mM cholic acid to deoxycholic acid and 3.7% to 7-keto-deoxycholic acid under anaerobic incubation[2]. E. lentum-like c-25 converts 91.5% of 150 mg/mL cholic acid to deoxycholic acid and 1.1% to 7-keto-deoxycholic acid under anaerobic incubation[2].

[References]

[1]. Sutherland JD, et al. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum. J Lipid Res. 1982 Jul;23(5):726-32.

[2]. Takahashi T, et al. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994 Nov;77(11):3275-86.

Chemical & Physical Properties

[ Density]:
1.18g/cm3

[ Boiling Point ]:
583ºC at 760mmHg

[ Melting Point ]:
54-60ºC

[ Molecular Formula ]:
C24H38O5

[ Molecular Weight ]:
406.55600

[ Flash Point ]:
320.4ºC

[ Exact Mass ]:
406.27200

[ PSA ]:
94.83000

[ LogP ]:
3.65690

[ Index of Refraction ]:
1.55

Safety Information

[ Hazard Codes ]:
T

Precursor & DownStream

Precursor

DownStream

Related Compounds