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opigolix

Names

[ CAS No. ]:
912587-25-8

[ Name ]:
opigolix

[Synonym ]:
VQ6CK0CITA
(1Z,2R)-N'-({5-[3-(2,5-Difluorophenyl)-2-(1,3-dihydro-2H-benzimidazol-2-ylidene)-3-oxopropanoyl]-2-fluorophenyl}sulfonyl)-2-hydroxypropanimidamide
UNII:VQ6CK0CITA
Opigolix
Propanimidamide, N'-[[5-[3-(2,5-difluorophenyl)-2-(1,3-dihydro-2H-benzimidazol-2-ylidene)-1,3-dioxopropyl]-2-fluorophenyl]sulfonyl]-2-hydroxy-, (1Z,2R)-
UNII-VQ6CK0CITA

Biological Activity

[Description]:

Opigolix is a Gonadotropin-releasing hormone (GnRH) receptor antagonist, used for the research of endometriosis and rheumatoid arthritis.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> GNRH Receptor
Research Areas >> Inflammation/Immunology

[Target]

GnRH receptor[1]


[In Vitro]

Opigolix (Compound 726) is a GnRH receptor antagonist, used for the research of sex hormone-dependent diseases, particularly GnRH-related diseases[1].

[References]

[1]. Hirano, Masaaki, et al. PROPANE-1,3-DION DERIVATIVE OR SALT THEREOF. WO 2006106812 A1.


[Related Small Molecules]

(Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH acetate salt | Alarelin | Cetrorelix Acetate | [D-Trp6]-LH-RH | (D-Ser(tBu)6,AzaGly10)-LHRH acetate salt | Deslorelin | Buserelin (Acetate) | elagolix | Relugolix | (D-2-Nal6)-LHRH acetate salt | Gonadorelin Acetate | (Des-Gly10,tBu-D-Gly6,Pro-NHEt9)-LHRH trifluoroacetate salt

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
706.9±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H19F3N4O5S

[ Molecular Weight ]:
544.502

[ Flash Point ]:
381.3±35.7 °C

[ Exact Mass ]:
544.102844

[ LogP ]:
0.45

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.665

Related Compounds