LY83583

Names

[ Name ]:
LY83583

[Synonym ]:
6-anilinoquinoline-5,8-dione
6-(Phenylamino)quinoline-5,8-dione
5,8-Quinolinedione, 6-(phenylamino)-
6-ANILINO-5,8-QUINOLINEDIONE
MFCD00210756

Biological Activity

[Description]:

LY83583 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase

[References]

[1]. Mülsch A, et al. LY 83583 (6-anilino-5,8-quinolinedione) blocks nitrovasodilator-induced cyclic GMP increases and inhibition of platelet activation. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jul;340(1):119-25.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
446.9±45.0 °C at 760 mmHg

[ Melting Point ]:
184-185°C

[ Molecular Formula ]:
C₁₅H₁₀N₂O₂

[ Molecular Weight ]:
250.252

[ Flash Point ]:
224.1±28.7 °C

[ Exact Mass ]:
250.074234

[ PSA ]:
59.06000

[ LogP ]:
1.56

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.715

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
0.1 M HCl: 1 mg/mL

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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Anticancer Drugs 25(10) , 1141-51, (2014)

The most important factors involved in tumor metastasis and angiogenesis are metalloproteinases (MMPs), vascular endothelial growth factor, and multifunctional transforming growth factor β1. These fac...

Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.

Plant Mol. Biol. 81(1-2) , 27-40, (2013)

Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone ...

Comparative study of the quercetin, ascorbic acid, glutathione and superoxide dismutase for nitric oxide protecting effects in mouse gastric fundus.

Eur. J. Pharmacol. 698(1-3) , 379-87, (2013)

The aim of this work was to compare the preventing capacity of quercetin with Cu/Zn superoxide dismutase (Cu/Zn SOD), ascorbic acid and glutathione on nitric oxide (NO)-induced relaxation in mouse gas...