Amaranth

Names

[ CAS No. ]:
915-67-3

[ Name ]:
Amaranth

[Synonym ]:
Amaranth Extra
Trisodium 3-hydroxy-4-[(4-sulfonato-1-naphthyl)diazenyl]-2,7-naphthalenedisulfonate
hidacid amaranth
l-rot3
FD & C Red No. 2
maple amaranth
Red dye No. 2
amaranth bpc
red no. 2
S-azo rubine
CI Food Red 9
Amaranth red
Rouge Solid E
C.I. food red 9
lissamine amaranth ac
takaoka amaranth
Trisodium 3-hydroxy-4-[(E)-(4-sulfonato-1-naphthyl)diazenyl]naphthalene-2,7-disulfonate
azo rubine sf
edicol amaranth
Amacid Amaranth
amaranth lake
3-Hydroxy-4-[(4-sulfo-1-naphthalenyl)azo]-2,7-naphthalenedisulfonic Acid Trisodium Salt
bordeaux s
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium salt
edicol supra amaranth a
naphthol red s
Naphthol Red S Specially Pure
Japan Red No. 2
Japan Food Red No. 2
hexacol amaranth b extra
amaranth wd
1508 red
tertracid red a
trisodium salt of 1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid
certicol amaranth s
aizen amaranth
Food Red No. 2
amaranth a
hd amaranth supra
hd amaranth b
Canacert Amaranth
D&C Red No. 2
acid amaranth i
Trisodium 3-hydroxy-4-[(E)-(4-sulfonato-1-naphthyl)diazenyl]-2,7-naphthalenedisulfonate
hexacert red no. 2
Amaranth
Amaranth USP
MFCD00004076
EINECS 213-022-2
acid amaranth n
kiton rubine s
Amaranth R
azo red r
kayaku food colour red no. 2
INS 123
Amaranth S Specially Pure
Cranberry Red
shikiso amaranth
trisodium 2-hydroxy-1-(4-sulfonato-1-naphthylazo)naphthalene-3,6-disulfonate
amaranth s
dolkwal amaranth
1-(4-sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic acid trisodium salt
san-ei amaranth
kayaku amaranth
trisodium 3-hydroxy-4-[(E)-(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2,7-disulfonate
amaranth b
toyo amaranth
Dye Red Raspberry
amarant
L Red Z 3050
1508red
1302 red
neklacid red a
acid leather rubine s
Naphthol Red S Conc. Specially Pure
Acid Amaranth J
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium salt
azo ruby s
Hidacid Amaranth 21-6008
1302red
fruit red a geigy
eurocert amaranth
3-Hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-2,7-naphthalenedisulfonic acid trisodium salt
redno.2
Azo Rubine S-FQ
rakuto amaranth
FD and Red No. 2
java amaranth
hispacid red am
L Red 3
naphthol red LZS
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(E)-2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:3)
Naphthol Red SI
solar red o
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthyl)azo]-, trisodium salt
Japan Red 2
kca foodcol amaranth a
azoredr
E123
C.I. Acid Red 27
Amaranth 85
FAST RED
2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[2-(4-sulfo-1-naphthalenyl)diazenyl]-, sodium salt (1:3)
acid amaranth
daishiki amaranth
azorubin s
c.i.184
Edicol Supra Amaranth AS
Acid Leather Red I 2BW

Biological Activity

[Description]:

Amaranth is a dark red to purple azo dye used as a food dye and to color cosmetics. Amaranth is an anionic dye. It can be applied to natural and synthetic fibers, leather, paper, and phenol-formaldehyde resins.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Dye Reagents

Research Areas >> Others

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.5

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C₂₀H₁₁N₂Na₃O₁₀S₃

[ Molecular Weight ]:
604.473

[ Flash Point ]:
44ºC

[ Exact Mass ]:
603.926880

[ PSA ]:
241.69000

[ LogP ]:
6.06870

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
50 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QJ6550000

CHEMICAL NAME :: 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-((4-sulfo-1-naphthyl)azo)-, trisodium salt

CAS REGISTRY NUMBER :: 915-67-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 36

MOLECULAR FORMULA :: C20-H11-N2-O10-S3.3Na

MOLECULAR WEIGHT :: 604.48

WISWESSER LINE NOTATION :: L66J BSWQ ENUN- BL66J CQ DSWQ HSWQ &-NA- 3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 96550 ug/kg/28D-C

TOXIC EFFECTS :: Liver - changes in liver weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 680 gm/kg/14W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1200 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1643 gm/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 548 mg/kg

SEX/DURATION :: female 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - menstrual cycle changes or disorders

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 547 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 33 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 65 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 296 mg/kg

SEX/DURATION :: multigenerations

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 548 mg/kg

SEX/DURATION :: male 52 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3528 ug/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4550 uL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 2 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4900 uL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12 mL/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 4 day(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 250 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16500 ug/kg

SEX/DURATION :: female 6-16 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 100 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 2 gm/L

REFERENCE :: GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,41,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2137 No. of Facilities: 1931 (estimated) No. of Industries: 9 No. of Occupations: 12 No. of Employees: 13075 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2137 No. of Facilities: 2272 (estimated) No. of Industries: 12 No. of Occupations: 22 No. of Employees: 13792 (estimated) No. of Female Employees: 5645 (estimated)

Safety Information

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QJ6550000

Precursor & DownStream

Precursor

DownStream

Articles

Evaluation of potential genotoxicity of five food dyes using the somatic mutation and recombination test.

Chemosphere 88(8) , 974-9, (2012)

In this study, different concentrations of five food dyes (amaranth, patent blue, carminic acid, indigotine and erythrosine) have been evaluated for genotoxicity in the Somatic Mutation and Recombinat...

Monoolein cubic phase containing acidic proteinoid: pH-dependent release.

Drug Dev. Ind. Pharm. 37(1) , 56-61, (2011)

Monoolein (MO) cubic phase containing acidic proteinoid was prepared for a pH-dependent release.The acidic proteinoid was prepared by a thermal-condensation reaction of Asp and Leu (9.85/0.15 in molar...

Genotoxicity assessment of amaranth and allura red using Saccharomyces cerevisiae.

Bull. Environ. Contam. Toxicol. 90(1) , 22-6, (2013)

Amaranth (E123) and Allura red (E129), very important food azo dyes used in food, drug, paper, cosmetic and textile industries, were assessed for their genotoxic potential through comet assay in yeast...