A 33
Names
[ CAS No. ]:
915082-52-9
[ Name ]:
A 33
Biological Activity
[Description]:
PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects.
[Related Catalog]:
Chemical & Physical Properties
[ Molecular Formula ]:
C19H18ClN3O2S
[ Molecular Weight ]:
387.88