SCH-900271

Names

[ Name ]:
SCH-900271

[Synonym ]:
unii-g2283xq6vj

Biological Activity

[Description]:

SCH-900271 is an orally active, potent nicotinic acid receptor (NAR) agonist with an EC50 of 2 nM in the hu-GPR109a assay. SCH-900271 exhibits dose-dependent inhibition of plasma free fatty acid (FFA). SCH-900271 has an improved therapeutic window to flushing[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Metabolic Disease

[Target]

EC50: 2.0 nM (hu-GPR109a), 96 nM (hu-GPR109b), 8.0 nM (rat-GPR109a), 6.0 nM (m-GPR109a) and 5.0 nM (dog-GPR109a)[1]

[References]

[1]. Anandan Palani, et al. Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett. 2011 Nov 24;3(1):63-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₆N₂O₄

[ Molecular Weight ]:
276.28800

[ Exact Mass ]:
276.11100

[ PSA ]:
96.45000

[ LogP ]:
2.11700