3-Aminopropyltriethoxysilane

Names

[ CAS No. ]:
919-30-2

[ Name ]:
3-Aminopropyltriethoxysilane

[Synonym ]:
3-(triethoxysilyl)propan-1-amine
MFCD00025614
1-Propanamine, 3-(triethoxysilyl)-
(3-Aminopropyl)triethoxysilane
(γ-Aminopropyl)triethoxysilane
3-aminopropyl-triethoxysilane
3-aminopropyltriethoxy silane
APTES
1-Propanamine, 3- (triethoxysilyl)-
3-aminopropyl triethoxysilane
3-(Triethoxysilyl)-1-propanamine
Propylamine, 3- (triethoxysilyl)-
γ-aminopropyltriethoxysilane
γ-Aminopropyltriethoxy silane
3-Aminopropyltriethoxysilane
EINECS 213-048-4
Silane, (γ-aminopropyl)triethoxy-
3-aminopropyl(triethoxy)silane
Aminopropyltriethoxysilane
KH-550

Biological Activity

[Description]:

3-Aminopropyltriethoxysilane is a common method for biomolecule immobilization on silicon and silicon derivatives such as silicon nitride (Si3N4)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Saengdee P, et al. Optimization of 3-aminopropyltriethoxysilane functionalization on silicon nitride surface for biomolecule immobilization. Talanta. 2020;207:120305.

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
222.1±13.0 °C at 760 mmHg

[ Melting Point ]:
-70 °C

[ Molecular Formula ]:
C₉H₂₃NO₃Si

[ Molecular Weight ]:
221.369

[ Flash Point ]:
104.4±0.0 °C

[ Exact Mass ]:
221.144714

[ PSA ]:
53.71000

[ LogP ]:
1.37

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.433

[ Storage condition ]:
Store at RT.

[ Stability ]:
Stable. Incompatible with acids, strong oxidizing agents. May decompose on exposure to moisture.

[ Water Solubility ]:
REACTS

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TX2100000

CHEMICAL NAME :: 1-Propanamine, 3-(triethoxysilyl)-

CAS REGISTRY NUMBER :: 919-30-2

BEILSTEIN REFERENCE NO. :: 1754988

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C9-H23-N-O3-Si

MOLECULAR WEIGHT :: 221.42

WISWESSER LINE NOTATION :: Z3-SI-O2&O2&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1233,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/19/1972

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1233,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1780 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 23,95,1962

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - emphysema Blood - changes in leukocyte (WBC) count

REFERENCE :: TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961- Volume(issue)/page/year: 11,118,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RCRVAB Russian Chemical Reviws (English Translation). Translation of USKHAB. (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.29- 1960- Volume(issue)/page/year: 38,975,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 mL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/19/1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CHABA8 Chemical Abstracts. (Chemical Abstracts Service, Box 3012, Columbus, OH 43210) V.1- 1907- Volume(issue)/page/year: 70,36149,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 147 mg/m3/6H/4W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0526411-2 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1992 No. of Facilities: 210 (estimated) No. of Industries: 6 No. of Occupations: 5 No. of Employees: 874 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1992 No. of Facilities: 1723 (estimated) No. of Industries: 22 No. of Occupations: 34 No. of Employees: 33590 (estimated) No. of Female Employees: 5422 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H314-H317

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2735 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
TX2100000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
29310095

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 29310095

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