Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]

Names

[ CAS No. ]:
919936-70-2

[ Name ]:
Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]

[Synonym ]:
4-(5-([(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfanyl)-1,3,4-oxadiazol-2-yl)pyridine

Biological Activity

[Description]:

GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK3α:415 nM (IC50)

GSK3β:521 nM (IC50)

[References]

[1]. Sophia Hu, et al. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity. Mol Cancer Ther. 2016 Jul;15(7):1485-1494.

Chemical & Physical Properties

[ Density]:
1.47±0.1 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
572.5±60.0 °C (760 mmHg)

[ Molecular Formula ]:
C₁₆H₁₁N₅O₂S

[ Molecular Weight ]:
337.35600

[ Exact Mass ]:
337.06300

[ PSA ]:
116.03000

[ LogP ]:
3.47390