Trichlormethiazide sodium

Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model[1][2].

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Trichlormethiazide (1 mg/kg; p.o.; once) sodium increases urinary volume, sodium and potassium excretion in rats[1]. Trichlormethiazide (10 mg/kg, i.v.; daily for 5 days) sodium significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group[2]. Animal Model: Male Wistar rats, weighing 170-300 g[1] Dosage: 1 mg/kg Administration: Oral administration, once Result: Significantly increased potassium excretion in normal rats. Significantly increased urinary volume, sodium and potassium excretion in cisplatin-induced ARF (acute renal failures) rats. Animal Model: Male Sprague-Dawley rats (350-450 g)[2] Dosage: 10 mg/kg Administration: Intravenous injection, daily, for 15 days Result: Produced a significant fall in MAP in rats on combined angiotensin II and high salt intake.

[1]. K Yao, et al. Diuretic effects of KW-3902, a novel adenosine A1-receptor antagonist, in various models of acute renal failure in rats. Jpn J Pharmacol. 1994 Apr;64(4):281-8.

[2]. J R Ballew, et al. Characterization of the antihypertensive effect of a thiazide diuretic in angiotensin II-induced hypertension. J Hypertens. 2001 Sep;19(9):1601-6.