<Suppliers Price>

STK321130

Names

[ CAS No. ]:
923562-23-6

[ Name ]:
STK321130

[Synonym ]:
5-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[4-(trifluoromethyl)benzyl]-2-pyridinamine
stk321130
2-Pyridinamine, 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-[[4-(trifluoromethyl)phenyl]methyl]-
FLT3-IN-2

Biological Activity

[Description]:

FLT3-IN-2 is a FLT3 inhibitor with IC50 of ＜ 1 μM, detailed information refer to WO 2012158957 A2 and WO 2007013896.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Research Areas >> Cancer

[References]

[1]. Zhang, Chao, et al. Kinase modulation for the treatment of leukemias. From PCT Int. Appl. (2012), WO 2012158957 A2 20121122.

[2]. Zhang Chao, et al. 7-Azaindole derivatives and their preparation, pharmaceutical compositions and use for modulating c-kit and c-fms activity. From PCT Int. Appl. (2007), WO 2007013896 A2 20070201.


[Related Small Molecules]

Gilteritinib | Quizartinib (AC220) | Pacritinib | Linifanib (ABT-869) | LY2784544 | DCC-2036 (Rebastinib) | Dovitinib (TKI-258, CHIR-258) | SB1317 | mrx-6313 | CHIR-124 | KW-2449 | ENMD-2076 | AST 487 | Tandutinib (MLN518) | TG101209

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C21H16ClF3N4

[ Molecular Weight ]:
416.827

[ Exact Mass ]:
416.101563

[ PSA ]:
53.60000

[ LogP ]:
5.86

[ Index of Refraction ]:
1.658

Related Compounds