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ABP 688

Names

[ CAS No. ]:
924298-51-1

[ Name ]:
ABP 688

[Synonym ]:
abp688

Biological Activity

[Description]:

ABP688 is a high affinity human mGluR5 antagonist with anKi of 1.7 nM. Radioisotope-labeled ABP688 can be used as a PET tracer for clinical imaging of the mGlu5 receptor[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> GPCR/G Protein >> mGluR

[Target]

human mGluR5:1.7 nM (Ki)


[References]

[1]. Hintermann S, et al. ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg Med Chem. 2007 Jan 15;15(2):903-14.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H16N2O

[ Molecular Weight ]:
240.30000

[ Exact Mass ]:
240.12600

[ PSA ]:
34.48000

[ LogP ]:
2.85420

Related Compounds