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TG100713

Names

[ CAS No. ]:
925705-73-3

[ Name ]:
TG100713

[Synonym ]:
cc-655
Phenol, 3-(2,4-diamino-6-pteridinyl)-
3-(2,4-Diamino-6-pteridinyl)phenol
Phenol,3-(2,4-diamino-6-pteridinyl)

Biological Activity

[Description]:

TG 100713 is an inhibitor of PI3K, with IC50s of 24, 50, 165, and 215 nM for PI3Kδ, γ, α and β isoforms respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kδ:24 nM (IC50)

PI3Kγ:50 nM (IC50)

PI3Kα:165 nM (IC50)

PI3Kβ:215 nM (IC50)


[In Vitro]

TG100713 (10 μM; 48 or 72 h) strongly inhibits endothelial cell (EC) proliferation[1].

[References]

[1]. Doukas J, et, al. Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
646.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H10N6O

[ Molecular Weight ]:
254.247

[ Flash Point ]:
344.8±34.3 °C

[ Exact Mass ]:
254.091614

[ PSA ]:
124.56000

[ LogP ]:
0.50

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.815

Related Compounds