AMTB hydrochloride
Names
[ CAS No. ]:
926023-82-7
[ Name ]:
AMTB hydrochloride
Biological Activity
[Description]:
AMTB hydrochloride is a selective TRPM8 channel blocker. AMTB hydrochloride inhibits icilin-induced TRPM8 channel activation with a pIC50 of 6.23. AMTB hydrochloride can be used for the research of the overactive bladder and painful bladder syndrome. AMTB hydrochloride is a non-selective inhibitor of voltage-gated sodium channels (NaV)[1][2].
[Related Catalog]:
[In Vitro]
AMTB hydrochloride blocks veratridine-induced membrane potential changes at each NaV1 isoform (pIC50s ranging 4.83-5.69 for NaV1.1- NaV1.8)[2]. AMTB hydrochloride decreases viable cell number in MDA-MB-231 and SK-BR-3 breast cancer cell lines (30 and 100 μM), and also reduces the migration of MDA-MB-231 cells (30 μM)[2].
[In Vivo]
In the anesthetized rat, AMTB (3 mg/kg; intravenous) hydrochloride decreases the frequency of volume-induced bladder contractions, without reducing the amplitude of contraction[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C23H27ClN2O2S
[ Molecular Weight ]:
430.99100
[ Exact Mass ]:
430.14800
[ PSA ]:
83.80000
[ LogP ]:
6.12900