BENOXATHIAN HCL

Names

[ Name ]:
BENOXATHIAN HCL

[Synonym ]:
2-[[[2-(2,6-Dimethoxyphenoxy)ethyl]-amino]-methyl]-1,4-benzoxathian hydrochloride
Benoxathian hydrochloride
Benoxathian HCl

Biological Activity

[Description]:

Benoxathian hydrochloride is a potent α1 adrenoceptor antagonist, can be used for researching anorexia[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

α1 Adrenoceptor[1]

[In Vivo]

Benoxathian hydrochloride (10 nM; paraventricular nucleus injection) completely reverses the anorexia induced by 2.5, 5.0 or 10.0 mg/kg Phenylpropanolamine (IP) in rats[1].

[References]

[1]. Wellman PJ, et al. Reversal of phenylpropanolamine anorexia in rats by the alpha-1 receptor antagonist benoxathian. Pharmacol Biochem Behav. 1991 Apr;38(4):905-8.

Chemical & Physical Properties

[ Boiling Point ]:
500.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₂₄ClNO₄S

[ Molecular Weight ]:
397.91600

[ Flash Point ]:
256.6ºC

[ Exact Mass ]:
397.11100

[ PSA ]:
74.25000

[ LogP ]:
4.41840

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Liquid chromatography-quadrupole time-of-flight mass spectrometry for screening in vitro drug metabolites in humans: investigation on seven phenethylamine-based designer drugs.

J. Pharm. Biomed. Anal. 114 , 355-75, (2015)

Phenethylamine-based designer drugs are prevalent within the new psychoactive substance market. Characterisation of their metabolites is important in order to identify suitable biomarkers which can be...

α1-Adrenergic drugs modulate differentiation and cell death of human erythroleukemia cells through non adrenergic mechanism.

Exp. Cell Res. 317(16) , 2239-51, (2011)

Preliminary data showed that α1-adrenergic antagonists induce apoptosis and a switch towards megakaryocytic differentiation in human erythroleukemia cells. To test the hypothesis whether survival and ...

Activated endothelial cells limit inflammatory response, but increase chemoattractant potential and bacterial clearance by human monocytes.

Cell Biol. Int. 39 , 721-32, (2015)

Inflammation is the normal immune response of vascularized tissues to damage and bacterial products, for which leukocyte transendothelial migration (TEM) is critical. The effects of cell-to-cell conta...