6-Oxohexanoic acid

Names

[ CAS No. ]:
928-81-4

[ Name ]:
6-Oxohexanoic acid

[Synonym ]:
Hexan-1-one-6-carboxylate
6-Oxohexanoate
6-OXO-HEXANOIC ACID
adipic semialdehyde
6-Oxohexanoic acid
monoaldehyde of adipic acid
6-oxo-n-hexanoic acid
1-hexanal-6-carboxylic acid
adipic acid monoaldehyde
5-carbohydroxy-1-pentanal
5-formylvaleric acid
Hexanoic acid,6-oxo
adipic monoaldehyde

Biological Activity

[Description]:

6-Oxohexanoic acid is a non-cleavable modified MMAF-C5-COOH linker and can be used in the synthesis of modified MMAF-C5-COOH, a drug-linker conjugate for ADC[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[In Vitro]

MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay[2].

[References]

[1]. Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection [published correction appears in Cancer Res. 2010 Feb 1;70(3):1275. Slaga, Dion S [added]]. Cancer Res. 2009;69(6):2358-2364.

[2]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006;17(1):114-124.

Chemical & Physical Properties

[ Density]:
1.088g/cm3

[ Boiling Point ]:
263.7ºC at 760mmHg

[ Molecular Formula ]:
C₆H₁₀O₃

[ Molecular Weight ]:
130.14200

[ Flash Point ]:
127.5ºC

[ Exact Mass ]:
130.06300

[ PSA ]:
54.37000

[ LogP ]:
0.83030

[ Index of Refraction ]:
1.441

Safety Information

[ HS Code ]:
2918300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%