Amino-PEG3-C2-Amine

Names

[ CAS No. ]:
929-75-9

[ Name ]:
Amino-PEG3-C2-Amine

[Synonym ]:
EINECS 213-206-2
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanamine
Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
2,2'-[Oxybis(ethylenoxy)]diethylamine
2,2'-[Oxybis(2,1-ethanediyloxy)]diethanamine
MFCD00628164
3,6,9-trioxaundecamethylenediamine

Biological Activity

[Description]:

Amino-PEG3-C2-Amine is a PEG-based (3 units) PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
291.1±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₂₀N₂O₃

[ Molecular Weight ]:
192.256

[ Flash Point ]:
131.8±16.8 °C

[ Exact Mass ]:
192.147400

[ PSA ]:
79.73000

[ LogP ]:
-1.94

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.462

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R37/38;R41

[ Safety Phrases ]:
S26-S39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Orthogonal, convergent syntheses of dendrimers based on melamine with one or two unique surface sites for manipulation.

J. Am. Chem. Soc. 123 , 8914 - 8922 , (2001)

An orthogonal, convergent route for the introduction of substoichiometric numbers of latent surface sites into dendrimers based on melamine is used to prepare targets that display one or two Boc-prote...

Non-natural glycosphingolipids and structurally simpler analogues bind HIV-1 recombinant Gp120.

Bioorg. Med. Chem. 10 , 625- 637, (2002)

Interactions of recombinant gp120 (rgp120) with non-natural glycosphingolipids (GSLs) and structurally simpler analogues have been studied using a competitive adhesion assay. Conjugates of cellobiosyl...

Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system.

Biomaterials 63 , 177-88, (2015)

Paracrine signals produced from stem cells influence tissue regeneration by inducing the differentiation of endogenous stem or progenitor cells. However, many recent studies that have investigated par...