Fosphenytoin

Names

[ Name ]:
Fosphenytoin

[Synonym ]:
fosphenyloin
Fosfenitoina
oxcarbamazepine
3-Phosphoryloxymethyl-diphenylhydantoin
HMPDP
Fosphenytoine
Fosphenytoinum
Prodilantin
Fosphenytoin
3-phosphoryloxymethyl-5,5-diphenylhydantoin

Biological Activity

[Description]:

Fosphenytoin is a phosphate ester prodrug developed as an alternative to intravenous phenytoin for acute intervention of seizures. Fosphenytoin has advantages including more convenient and rapid intravenous administration, availability for intramuscular injection, and low potential for adverse local reactions at injection sites[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Fischer JH, et al. Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures. Clin Pharmacokinet. 2003;42(1):33-58.

Chemical & Physical Properties

[ Density]:
1.495g/cm3

[ Molecular Formula ]:
C₁₆H₁₅N₂O₆P

[ Molecular Weight ]:
362.27

[ Exact Mass ]:
362.06700

[ PSA ]:
125.98000

[ LogP ]:
1.81550

[ Index of Refraction ]:
1.63

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%