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Elinogrel

Names

[ CAS No. ]:
936500-94-6

[ Name ]:
Elinogrel

[Synonym ]:
2-Thiophenesulfonamide, 5-chloro-N-[[[4-[6-fluoro-1,4-dihydro-7-(methylamino)-2,4-dioxo-3(2H)-quinazolinyl]phenyl]amino]carbonyl]-
5-Chloro-N-({4-[6-fluoro-7-(methylamino)-2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl]phenyl}carbamoyl)-2-thiophenesulfonamide
Elinogrel
UNII-915Y8E749J

Biological Activity

[Description]:

Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible platelet P2Y12 antagonist (IC50=20 nM). It is orally and intravenously available and has potent antiplatelet effects[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

[Target]

IC50: 20 nM (P2Y12)[2]


[References]

[1]. Angiolillo DJ, et al. Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudyfrom the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (INNOVATE-PCI) trial. Circ Cardiovasc Interv. 2012 Jun;5(3):347-56.

[2]. Jacobson KA, et al. Pharmacochemistry of the platelet purinergic receptors. Purinergic Signal. 2011 Sep;7(3):305-24.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C20H15ClFN5O5S2

[ Molecular Weight ]:
523.945

[ Exact Mass ]:
523.018738

[ PSA ]:
182.53000

[ LogP ]:
3.02

[ Index of Refraction ]:
1.706

Related Compounds