Neurodazine

Names

[ Name ]:
Neurodazine

[Synonym ]:
1H-Imidazole, 2-[5-(3-chlorophenyl)tetrahydro-2-furanyl]-4,5-bis(4-methoxyphenyl)-
Neurodazine
2-[5-(3-Chlorophenyl)tetrahydro-2-furanyl]-4,5-bis(4-methoxyphenyl)-1H-imidazole

Biological Activity

[Description]:

Neurodazine is an imidazole-based small molecule, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways. Neurodazine selectively suppresses astrocyte differentiation of P19 cells[1][2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Hedgehog

Signaling Pathways >> Stem Cell/Wnt >> Wnt

[References]

[1]. Kim GH, et al. Imidazole-based small molecules that promote neurogenesis in pluripotent cells. Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9271-4.

[2]. Halder D, et al. Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. Mol Biosyst. 2015 Oct;11(10):2727-37.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
669.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₁ClN₂O₃

[ Molecular Weight ]:
460.952

[ Flash Point ]:
358.4±31.5 °C

[ Exact Mass ]:
460.155365

[ PSA ]:
56.37000

[ LogP ]:
6.42

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.613

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H318-H413

[ Precautionary Statements ]:
P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

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Front. Endocrinol. (Lausanne.) 2 , 117, (2011)

The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer's disease (AD) brains. In parallel, the...

Role of ciliary neurotrophic factor in the proliferation and differentiation of neural stem cells.

J. Alzheimers Dis. 37(3) , 587-92, (2013)

Ciliary neurotrophic factor (CNTF) is a pleiotropic cytokine that has been fully studied for its structure, receptor, and signaling pathways and its multiplex effects on neural system, skeletal muscle...