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p53 and MDM2 proteins-interaction-inhibitor (racemic)

Names

[ CAS No. ]:
939983-14-9

[ Name ]:
p53 and MDM2 proteins-interaction-inhibitor (racemic)

[Synonym ]:
2-(4-((4R,5S)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)-1-morpholinoethanone
p53 and MDM2 proteins-interaction-inhibitor racemic
p53 and MDM2 proteins-interaction-inhibitor (racemic)

Biological Activity

[Description]:

p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins.

[Related Catalog]:

Signaling Pathways >> Apoptosis >> MDM-2/p53
Research Areas >> Cancer

[References]

[1]. Vu B, et al. Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development. ACS Med Chem Lett. 2013 Apr 2;4(5):466-9.


[Related Small Molecules]

Pifithrin-α hydrobromide | RG7388 | Nutlin-3a | AMG232 | Pifithrin-β (hydrobromide) | Stylomycin aminonucleoside | RG7112 | APR-246 | NVP-HDM201 | SAR 405838 | RITA (NSC 652287) | NVP-CGM097 | Tenovin-1 | SJ 172550

Chemical & Physical Properties

[ Density]:
1.24

[ Molecular Formula ]:
C40H49Cl2N5O4

[ Molecular Weight ]:
734.75400

[ Exact Mass ]:
733.31600

[ PSA ]:
77.92000

[ LogP ]:
6.36620

[ Storage condition ]:
2-8℃

Related Compounds