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Chlorahololide D

Names

[ CAS No. ]:
943136-39-8

[ Name ]:
Chlorahololide D

[Synonym ]:
[(1aR,1bS,2R,4Z,8aR,9S,9aS,10aR,10bS,10cS,11bS)-7-(Acetoxymethyl)-2,9-dihydroxy-4-(1-methoxy-1-oxo-2-propanylidene)-1b,10b-dimethyl-3,6-dioxo-1,1a,1b,2,3,4,4a,6,8,8a,9,9a,10,10a,10b,10c,11,11b-octadecahydrocyclopropa[4,5]cyclopropa[4',5']cyclopenta[1',2':7,8]acephenanthryleno[10a,10-b]furan-9-yl]methyl (2E)-2-methyl-2-butenoate
2-Butenoic acid, 2-methyl-, [(1aR,1bS,2R,4Z,8aR,9S,9aS,10aR,10bS,10cS,11bS)-7-[(acetyloxy)methyl]-1,1a,1b,2,3,4,4a,6,8,8a,9,9a,10,10a,10b,10c,11,11b-octadecahydro-2,9-dihydroxy-4-(2-methoxy-1-methyl-2-oxoethylidene)-1b,10b-dimethyl-3,6-dioxocyclopropa[4,5]cyclopropa[4',5']cyclopent[1',2':7,8]acephenanthryleno[10a,10-b]furan-9-yl]methyl ester, (2E)-

Biological Activity

[Description]:

Chlorahololide D is a potent and selective Potassium Channel blocker with an IC50 value of 2.7 µM. Chlorahololide D is a nature product that could be isolated from the whole plant of Chloranthus holostegius[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[References]

[1]. Ping YS, et, al. Chlorahololides C–F: a new class of potent and selective potassium channel blockers from Chloranthus holostegius. Tetrahedron. 2008 Feb 25;64(9): 2027-34.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
833.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C38H44O11

[ Molecular Weight ]:
676.749

[ Flash Point ]:
259.4±27.8 °C

[ Exact Mass ]:
676.288391

[ PSA ]:
162.73000

[ LogP ]:
3.08

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.630

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds