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DPC AJ1951

Names

[ CAS No. ]:
943519-33-3

[ Name ]:
DPC AJ1951

Biological Activity

[Description]:

DPC-AJ1951, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR) , and characterized its activity in ex vivo and in vivo assays of bone resorption[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Others >> Thyroid Hormone Receptor

[In Vitro]

DPC-AJ1951 induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR (EC50 26±14 nM)[1][1].

[References]

[1]. Percy H Carter, et al. Discovery of a Small Molecule Antagonist of the Parathyroid Hormone Receptor by Using an N-terminal Parathyroid Hormone Peptide Probe. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6846-51.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H29FN6O7

[ Molecular Weight ]:
448.45

Related Compounds