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Apararenone

Names

[ CAS No. ]:
945966-46-1

[ Name ]:
Apararenone

[Synonym ]:
Methanesulfonamide, N-[4-(4-fluorophenyl)-3,4-dihydro-2,2-dimethyl-3-oxo-2H-1,4-benzoxazin-7-yl]-
UNII:832663U2NB
832663U2NB
N-[4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl]methanesulfonamide
apararenone

Biological Activity

[Description]:

Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Mineralocorticoid Receptor
Research Areas >> Metabolic Disease
Research Areas >> Cardiovascular Disease

[Target]

Mineralocorticoid receptor[1]


[In Vivo]

Recently, a phase II clinical trial has been initiated among patients with non-alcoholic steatohepatitis (NASH) in Japan[1].

[References]

[1]. Kolkhof P, et al. 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development. J Endocrinol. 2017 Jul;234(1):T125-T140.


[Related Small Molecules]

Eplerenone | Esaxerenone | Fludrocortisone acetate | Deoxycorticosterone acetate | Canrenone | Osilodrostat | SC26304

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
594.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H17FN2O4S

[ Molecular Weight ]:
364.391

[ Flash Point ]:
313.2±32.9 °C

[ Exact Mass ]:
364.089294

[ LogP ]:
1.26

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.610

[ Storage condition ]:
2-8℃

Related Compounds