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Ontuxizumab

Names

[ CAS No. ]:
946415-62-9

[ Name ]:
Ontuxizumab

Biological Activity

[Description]:

Ontuxizumab (MORAb-004) is a humanized IgG1/κ anti-endosialin (TEM-1 or CD248) monoclonal antibody with antitumor effects. Ontuxizumab can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Ontuxizumab (0-100 μg/mL；12 小时) 诱导 CD248 内化并剂量依赖性地降低了 46% 的人周皮细胞表面的 CD248[1]。

[In Vivo]

Ontuxizumab (50 mg/kg；静脉注射，每天 5 次，连续 5 天) 在人 CD248 敲入小鼠显示抗肿瘤作用[1]。 Animal Model: Human CD248 knock-in mice[1] Dosage: 50 mg/kg Administration: Intravenous injection via tail vein; 50 mg/kg, 5 doses daily for 5 consecutive days Result: Reduced tumor growth with a lower level of CD248 and α-SMA on neovasculature pericytes.

[References]

[1]. Rybinski K, et al. Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature. Oncotarget. 2015 Sep 22;6(28):25429-40.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds