Cyclohexanamine,N-cyclohexyl-N-nitroso-

Names

[ CAS No. ]:
947-92-2

[ Name ]:
Cyclohexanamine,N-cyclohexyl-N-nitroso-

[Synonym ]:
N-dicyclohexylnitrosamine
N-cyclohexyl-N-nitrosocyclohexanamine
DICYCLOHEXYLAMINE,N-NITROSO
N-Nitrosodicyclohexylamin
Dicyclohexylnitrosamine
Dicyclohexyl-nitroso-amin
dicyclohexyl-nitroso-amine
Cyclohexanamine,N-cyclohexyl-N-nitroso
Dicyclohexylnitrosamin
N-Nitrosodicyclohexylamine

Biological Activity

[Description]:

N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Others >> Androgen Receptor

[References]

[1]. Hari, Sayaka, et al. (2006). Anti-Androgenic Activity of N-Nitrosodibenzylamine, N-Nitrosodiphenylamine and N-Nitrosodicyclohexylamine. JOURNAL OF HEALTH SCIENCE, 52(5), 522-531.

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
352.9ºC at 760mmHg

[ Melting Point ]:
95-97ºC

[ Molecular Formula ]:
C₁₂H₂₂N₂O

[ Molecular Weight ]:
210.31600

[ Flash Point ]:
167.3ºC

[ Exact Mass ]:
210.17300

[ PSA ]:
32.67000

[ LogP ]:
3.63520

[ Index of Refraction ]:
1.582

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HY4300000

CHEMICAL NAME :: Dicyclohexylamine, N-nitroso-

CAS REGISTRY NUMBER :: 947-92-2

BEILSTEIN REFERENCE NO. :: 1842001

LAST UPDATED :: 199710

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H22-N2-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7. Volume(issue)/page/year: 69,103,1967