α-Hemolysin (Staphylococcus aureus)

[Description]:

α-Hemolysin (Staphylococcus aureus) is one of the most characteristic virulence factors secreted by Staphylococcus aureus, a polypeptide capable of destroying the host cell plasma membrane. After α-Hemolysin binds to the cell surface, its monomers assemble into a homoheptamer to form a front pore, which then transforms into a mature transmembrane pore water channel, allowing K+ and Ca2+ ion transport, leading to necrotic death of target cells[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

α-Hemolysin (Staphylococcus aureus) 在 THP-1 细胞中可诱导 IL-1β 分泌和 caspase-1 激活，且是通过 NLRP3-炎性体依赖性 caspase-1 的激活诱导 IL-1β 分泌[1]。 α-Hemolysin (Staphylococcus aureus)(1 µg/mL, 4h) 可以诱导 THP 衍生细胞死亡，需要宿主 NLRP3 信号传导，但不依赖于 caspase-1 激活和 IL-1β 分泌[1]。

[References]

[1]. Robin R Craven, et al. Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells. PLoS One. 2009 Oct 14;4(10):e7446.

[ Appearance of Characters ]:
lyophilized powder

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble0.49 - 0.51mg/mL

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-21/22

[ Safety Phrases ]:
36-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Staphylococcal alpha toxin--recent advances.

Toxicon 26 , 55-65, (1988)

The elucidation of the amino acid sequence of alpha toxin in 1984 has greatly promoted our understanding of the basic biochemistry and interaction of this toxin with membranes. These aspects are discu...

Adaptation to benzalkonium chloride and ciprofloxacin affects biofilm formation potential, efflux pump and haemolysin activity of Escherichia coli of dairy origin.

J. Dairy Res. 79(4) , 383-9, (2012)

The present study investigates the effect of adaptive resistance to ciprofloxacin (Cip) and benzalkonium chloride (BC) on biofilm formation potential (BFP), efflux pump activity (EPA) and haemolysin a...

A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.

J. Histochem. Cytochem. 183 , 3942-8, (2009)

The mechanism by which bacterial pathogens activate caspase-1 via Nlrp3 remains poorly understood. In this study, we show that the ability of Staphylococcus aureus, a leading cause of infection in hum...

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