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Compound 48/80

Names

[ CAS No. ]:
94724-12-6

[ Name ]:
Compound 48/80

[Synonym ]:
Benzenediazonium,2-carboxy-,chloride
MFCD00077679
compound 48/80
benzenediazonium 2-carboxylate hydrochloride
2-Carboxy-benzoldiazonium,Chlorid
o-carboxybenzenediazonium chloride
2-carboxy-benzenediazonium chloride
benzeneethanamine-4-methoxy-3,5-bis{(2-methoxy-5-(2-methylaminoethyl)phenyl)methyl-N-methyl}

Biological Activity

[Description]:

Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

Mast Cell Activator[1]


[In Vitro]

Compound 48/80 (poly-p-methoxyphenethylmethylamine), an agent commonly used to trigger degranulation of mast cells, at concentrations of 5-20 μg/ml suppresses the proliferation of L1210 and Friend leukemic cells in vitro, inducing the formation of giant cells, which are polykaryons[3].

[References]

[1]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104.

[2]. Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124.

[3]. Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H45N3O3

[ Molecular Weight ]:
519.72

[ Exact Mass ]:
597.34600

[ PSA ]:
63.78000

[ LogP ]:
6.95640

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
22-24/25-45-36/37

[ RIDADR ]:
UN 2811 6.1/PG 2

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds