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3-O-Methyl-N-acetyl-D-glucosamine

Names

[ CAS No. ]:
94825-74-8

[ Name ]:
3-O-Methyl-N-acetyl-D-glucosamine

[Synonym ]:
3-O-Methyl-N-acetyl-D-glucosamine
N-Acetyl-3-O-methyl-D-glucosamine
2-Acetamido-2-deoxy-3-O-methyl-D-glucopyranose
3-O-OME-GLCNAC
2-Acetylamino-O3-methyl-2-desoxy-D-glucose
2-acetylamino-O3-methyl-2-deoxy-D-glucose
2-Acetamido-2-deoxy-3-O-methyl-D-glucose
2-ACETAMIDO-2-DEOXY-3-O-METHYL-D-GLUCOPYRANOSE,OFF-WHITE SOLID
3-OME-GLCNAC

Biological Activity

[Description]:

3-O-Methyl-N-acetyl-D-glucosamine is a potent inhibitor of N-acetylglucosamine kinase. 3-O-Methyl-N-acetyl-D-glucosamine potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

N-acetylglucosamine kinase[1]


[References]

[1]. Miwa I, et al. Utility of 3-O-methyl-N-acetyl-D-glucosamine, an N-acetylglucosamine kinase inhibitor, for accurate assay of glucokinase in pancreatic islets and liver. Enzyme Protein. 1994;48(3):135-142.

Chemical & Physical Properties

[ Density]:
1.368g/cm3

[ Boiling Point ]:
542.355ºC at 760 mmHg

[ Melting Point ]:
189-191ºC

[ Molecular Formula ]:
C9H17NO6

[ Molecular Weight ]:
235.23400

[ Flash Point ]:
281.806ºC

[ Exact Mass ]:
235.10600

[ PSA ]:
108.25000

[ Index of Refraction ]:
1.534

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds