2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl-

Names

[ CAS No. ]:
950-99-2

[ Name ]:
2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl-

[Synonym ]:
PMHCR
2H-1-Benzopyran-6-ol,3,4-dihydro-2,2,5,7,8-pentamethyl
2,2,5,7,8-pentamethyl-6-hydroxy-chromane
MFCD00210347
Chromane C1
6-Hydroxy-2,2,5,7,8-pentamethylchroman
2,2,5,7,8-pentamethylchroman-6-ol
2,2,5,7,8-Pentamethyl-1-hydroxychroman
2,2,5,7,8-Pentamethyl-6-hydroxychroman
2,2,5,7,8-Pentamethyl-6-chromanol
Chroman C1

Biological Activity

[Description]:

2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Androgen Receptor

[References]

[1]. Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.

Chemical & Physical Properties

[ Density]:
1.034g/cm3

[ Boiling Point ]:
344.3ºC at 760 mmHg

[ Melting Point ]:
89-91ºC(lit.)

[ Molecular Formula ]:
C₁₄H₂₀O₂

[ Molecular Weight ]:
220.30700

[ Flash Point ]:
146.1ºC

[ Exact Mass ]:
220.14600

[ PSA ]:
29.46000

[ LogP ]:
3.42100

[ Index of Refraction ]:
1.529

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%