Boc-N-Amido-PEG2-C2-azide

Names

[ Name ]:
Boc-N-Amido-PEG2-C2-azide

[Synonym ]:
BOC-NH-PEG(2)-N3 1-(T-BUTYLOXYCARBONYL-AMINO)-3,6-DIOXA-8-OCTANEAZIDE
tert-Butyl 2-(2-azidoethoxy)ethoxyethylcarbamate

Biological Activity

[Description]:

Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₂₂N₄O₄

[ Molecular Weight ]:
274.31700

[ Exact Mass ]:
274.16400

[ PSA ]:
106.54000

[ LogP ]:
1.69826

Boc-N-Amido-PEG2-C2-azide

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds